Fmoc-β-Ala-D-Cit-OH Pharmaceutical Impurity For Peptide Building Block

High-purity Fmoc-β-Ala-D-Cit-OH for Impurity Research and pharmaceutical development.

Core application in Solid-Phase Peptide Synthesis:

• Used as a β-Ala–D-Cit dipeptide fragment

• Fmoc protects the N-terminus for stepwise elongation

• C-terminal –COOH enables further coupling

• Citrulline side chain is stable and does not require strong protection (compared to Arg)

Advantages:

• reduces synthesis steps

• avoids side reactions from arginine guanidine group

• improves synthesis reliability

One of the most important uses:

• In peptide design, Arg → Cit substitution is widely used

• Citrulline removes the positive charge of arginine

Impact:

• alters binding affinity

• changes biological activity

• improves selectivity

Typical in:

• enzyme substrate studies

• receptor interaction optimization

Citrulline is closely related to the arginine–NO (nitric oxide) pathway.

Applications:

• nitric oxide related peptides

• cardiovascular research peptides

• metabolic and signaling pathway studies

Used in designing:

• therapeutic peptides

• immune-related peptides

• anti-inflammatory peptides

Benefits:

• neutral side chain vs Arg → better pharmacokinetics

• improved stability and solubility balance

The β-Ala residue adds flexibility:

• acts as a linker/spacer

• reduces steric hindrance

• adjusts distance between functional residues

Small packages (1g, 25g, 1Kg, 25Kg) can be shipped by Express (DHL, FedEx, EMS, etc.). Large packages (100kg and more than 100Kg) can be transported by Air or Sea. All transportation is arranged according to customer requirements.