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Certificat
Fmoc-β-Ala-Phe-OH SPPS Amino Acid Impurity Research Coupling Efficiency
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Détails sur le produit:
Conditions de paiement et expédition:
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Description de produit détaillée
| Nom du produit: | Fmoc-β-Ala-Phe-OH | N° CAS: | N / A |
|---|---|---|---|
| MW: | 387.43 | apparence: | Poudre blanche |
| HPLC: | 99% | Stockage: | température ambiante |
Fmoc-β-Ala-Phe-OH SPPS Amino Acid Impurity Research
High-purity Fmoc-β-Ala-Phe-OH for Impurity Research and peptide development.
| Name | Fmoc-β-Ala-Phe-OH |
|---|---|
| CAS NO | NA |
| Molecular Weight | 387.43 |
| Appearance | White Powder |
| HPLC Purity | 99%+ |
| Synonyms | Fmoc-beta-Ala-Phe-OH |
Key Applications
1. Solid-Phase Peptide Synthesis (SPPS)
This is the primary application.
- Used as a dipeptide building block in peptide chain elongation
- Compatible with the Fmoc strategy (base-labile protecting group)
- The β-alanine unit:
- Introduces extra flexibility
- Reduces steric hindrance
- Improves coupling efficiency in certain sequences
2. Peptide Drug Design
This structure is useful in medicinal chemistry:
- β-Ala acts as a flexible linker
- Phe (phenylalanine) provides hydrophobic and aromatic interactions
Typical purposes:
- Optimization of receptor binding (especially GPCR-related peptides)
- Improving biological activity and selectivity
- Modulating metabolic stability
3. Linker / Spacer Component
Widely used as a spacer unit in complex systems:
- PEGylation
- Peptide–small molecule conjugates
- Drug delivery systems
β-Ala offers a longer and more flexible spacer than Glycine
Coordonnées
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